专题学术讲座| Jeffery S. Cox: Using global proteomics to discover new anti-TB pathways of macrophages

来源:科研管理账号 发布时间:2019-04-19 作者: 阅读数:587次

时间:2019423日(周二)14:00-15:00

Time: 14:00-15:00, Tuesday, 23 April 2019

地点:西湖大学云栖校区5号楼学术报告厅

Venue: Lecture Hall, Building 5, Yunqi Campus

主持人:西湖大学校长、结构生物学讲席教授 施一公

Host: Yigong Shi, Chair Professor, President of Westlake University

 

主讲嘉宾:



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Jeffery S. Cox

C.H. Li Chair of Biochemistry and Molecular Endocrinology, Professor of Immunology and Pathogenesis, Dept of Molecular & Cell Biology, UC Berkeley

 

Research Expertise and Interest:

TB, Mycobacterium tuberculosis, M. tuberculosis, genetics, proteomics, transcriptional profiling, host-pathogen interactions, host-directed therapy.

 

Abstract:

Macrophages are innate immune cells critical for controlling many bacterial infections, including tuberculosis. However, many pathogens, including Mycobacterium tuberculosis, can hijack these cells and use them as sites of replication. The pathways that control intracellular bacterial growth and how they are manipulated by pathogens are not well understood. We have utilized cutting-edge mass spectrometry techniques to comprehensively probe the interactions between macrophages and three intracellular bacterial pathogens, M. tuberculosis, Salmonella and Listeria. Monitoring both host-microbe protein-protein interactions and host post-translational modification has uncovered new targets and pathways that influence antibacterial responses and bacterial growth. Our results revealed thousands of ubiquitylation and phosphorylation events that occur early after infection, most of which were previously unknown. Unlike transcriptional responses to bacterial infection, which are largely monotonic, our results reveal a surprising diversity in ubiquitin-mediated responses to each pathogen. Likewise, using well-defined attenuated bacterial mutants revealed a remarkable ability of macrophages to discriminate virulent from non-virulent bacteria, suggesting macrophages can integrate information about the nature of the engulfed bacteria and elicit unique responses. These studies have uncovered a unique mechanism by which bacterial pathogens suppress antibacterial immune responses by activating inappropriate antiviral innate responses.


联系人: 科技合作部     沈老师      shenxiaolian@westlake.edu.cn