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李旭博士


Xu Li, Ph. D.  



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一、个人简介

李旭,2004年毕业于清华大学生命科学与技术系,获得学士学位。2009年毕业于美国南加州大学药学院,获得分子药理与毒理学博士学位。2010-2011年在美国希望之城国家医学中心进行博士后研究工作,研究方向为利用分子药理学方法阐释肿瘤抗药性的机理。2011-2016年在德克萨斯大学安德森癌症中心进行博士后研究工作,2016年被安德森癌症中心聘为讲师。2018年2月全职回国加入浙江西湖高等研究院。


二、学术成果

李旭博士的研究主要以基于质谱的蛋白质组学及生物信息学方法,系统研究肿瘤形成中重要的信号通路与蛋白家族,包括Hippo,Wnt,Notch等信号通路及转录因子,蛋白酪氨酸磷酸酶,周期蛋白依赖性激酶,有丝分裂原活化蛋白激酶,端锚聚合酶等蛋白家族。通过建立这些信号通路与蛋白家族的相互作用组,并从中筛选出高可信度的蛋白进行后续的功能验证,为癌症治疗提供药理基础、生物标记和药物靶点。

实验室未来的科研方向是结合高通量质谱技术、大数据分析与分子生物学实验方法,研究和认识蛋白质的转译后修饰与蛋白质之间的相互作用如何影响基因转录、发育以及疾病的发生和发展。通过在发育、衰老和疾病过程中对蛋白质表达、活性和招募的研究,以及对蛋白质转译后修饰和相互作用的动态变化的研究,寻找新的生物标记与药物作用靶点,为肿瘤和多种神经退行性疾病、免疫系统疾病的发病机制、预防和治疗提供科学理论基础。

 

三、代表文章

* These authors contributed equally

1. Li X*, Han H*, Zhou MT*, Yang B, Ta AP, Chen J, Wang W. (2017) Proteomic analysis of tankyrase protein interaction network reveals its role in pexophagy. Cell Rep. 20:737-749

2. Li X*, Gao M*, Choi JM, Kim   BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J. (2017)   Clustered, Regularly Interspaced Short Palindromic Repeats   (CRISPR)/Cas9-coupled Affinity Purification/Mass Spectrometry Analysis   Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol  Cell Proteomics 16:594-607

3. Li X, Tran MK, Sorokin AK,   Chen J, Wang W. (2016) Defining protein-protein interaction network for human   protein tyrosine phosphatase family. Mol Cell Proteomics 15:3030-44

4. Li X*, Wang W*, Xi Y, Gao M,   Aziz KE, Tran MK, Qin J, Li W, Chen J. (2016) FOXR2 interacts with MYC to   promote its transcriptional activities and tumorigenesis. Cell  Rep. 16:487-497

5. Li X*, Wang W*, Wang J,   Malovannaya A, Xi Y, Li W, Guerra R, Hawke DH, Qin J, Chen J. (2015)   Proteomic analyses reveal distinct chromatin-associated and soluble   transcription factor complexes. Mol Syst Biol. 11:775 

6. Wang W*, Li X*,   Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J.   (2015) FOXKs promote Wnt/β-catenin signaling by translocating DVL into the   nucleus. Dev Cell 32:707-18

7. Li   X, Wang   W, Chen J. (2015) From pathways to networks: connecting dots by establishing   protein-protein interaction networks in signaling pathways using affinity   purification and mass spectrometry. Proteomics 15:188-202

8. Wang W*, Li X*,   Huang J, Feng L, Dolinta KG, Chen J. (2014) Defining the protein-protein   interaction network of the human hippo pathway. Mol Cell Proteomics   13:119-31

9. Xu S*, Li X*, Gong   Z*, Wang W, Li Y, Chandrasekharan BN, Piao H, Yang K, Wu G, Chen J. (2014)   Proteomic analysis of the human cyclin-dependent kinase family reveals a   novel CDK5 complex involved in cell growth and migration. Mol   Cell Proteomics 13:2986-3000

10. Kuo CY*, Li X*,   Kong XQ, Luo C, Chang CC, Chung Y, Shih HM, Li KK, Ann DK. (2014) An   arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment   and degradation of the phosphorylated and SUMOylated Krüppel-associated box   domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress. J   Biol Chem. 289:20757-72

11. Li X, Lin HH, Chen H, Xu X, Shih HM, Ann DK. (2010) SUMOylation of   the transcriptional co-repressor KAP1 is regulated by the serine and   threonine phosphatase PP1. Sci Signaling 3:ra32

12. Li X, Lee YK, Jeng   JC, Yen Y, Schultz DC, Shih HM, Ann DK. (2007) Role for KAP1 serine   824 phosphorylation and sumoylation/desumoylation switch in regulating   KAP1-mediated transcriptional repression. J Biol Chem. 282: 36177-89


查看全部25篇共同作者文章:

https://scholar.google.com/citations?user=Ep32NXsAAAAJ&hl=en


 

     四、联系方式

     电子邮箱: lixu@westlake.edu.cn