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解明岐

Mingqi Xie, Ph.D.


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一、   个人简介

解明岐(1987-),博士,师从著名哺乳动物合成生物学大师Martin Fussenegger教授。解明岐博士成长于德国,在海外完成其所有学业,精通德、中、英、法等多国语言,并于2017年在瑞士苏黎世联邦理工大学(ETH Zürich)获得博士学位。解明岐博士长期从事合成生物学和代谢疾病治疗相关领域研究,主要涉及基因调控、细胞工程和细胞治疗等多个研究方向,并作为项目负责人或科研骨干主持/参与多个欧盟科研课题。解明岐博士将于2019年9月全职加入西湖大学生命科学学院,担任研究员、助理教授(独立PI)一职,将继续从事合成生物学和细胞治疗相关研究。

 

二、   学术成果

代谢性疾病是危及人类健康的系统性疾病。尽管近年来代谢性疾病的临床诊疗取得了长足进步,但现有的技术水平尚无法实现对患者血液循环中的分子指标进行实时监测,也无法实现在最恰当的时刻为患者提供与病情严重程度相匹配的药物治疗,这是当前医学界的重大难题。解明岐博士凭借着合成生物学技术,对哺乳动物细胞进行独特的精准调控,从而设计出可自主治疗多种代谢病的“智能细胞”(Designer cells)。植入患者体内后,智能细胞犹如一个特异的生物处理器,可有效地识别与测定血液中各种疾病标志物,从而精准而实时地调节药物蛋白在人体内的生产和释放。解明岐博士设计、合成的人工类β细胞(β-cell-mimetic designer cells)能够实时检测葡萄糖等分子指标,并相应地生产和释放胰岛素等药物蛋白,从而实现糖尿病等代谢性疾病的自动化医疗。在未来,将实现自动化治疗的各类智能细胞有望革命性地取代医学上的多种传统诊断、治疗和防御措施。目前,解明岐博士主持或参与设计的针对糖尿病、肝损伤和神经性疼痛等多种智能细胞治疗方案总共在国际顶级学术期刊上发表论文11 篇、综述4篇,引起了国际媒体的广泛关注和学术同行的正面引用。

 

三、   代表论文

 *: co-first author

1、Xie, M. and Fussenegger, M. Designing cell function: assembly of synthetic gene circuits for cell-biology applications. Nature Reviews Molecular Cell Biology (2018) 19, 507-525.

 

2、Xie, M., Ye, H., Wang, H., Charpin-El Hamri, G., Lormeau, C., Saxena, P., Stelling, J. and Fussenegger, M. β-cell-mimetic designer cells provide closed-loop glycemic control. Science (2016) 354, 1296-1301.

 

3、Xie, M., Ye, H., Charpin El-Hamri, G. and Fussenegger, M. Antagonistic control of a dual-input mammalian gene switch by food additives. Nucleic acids research (2014) 42, e116.

 

4、Ye, H.*, Xie, M.*, Xue, S., Charpin-El Hamri, G., Yin, J., Zulewski, H. and Fussenegger, M.  Self-adjusting synthetic gene circuit for correcting insulin resistance. Nature Biomedical Engineering (2017) 1, 5.

 

5、Folcher, M.*, Xie, M.*, Spinnler, A. and Fussenegger, M. Synthetic mammalian trigger-controlled bipartite transcription factors. Nucleic acids research (2013) 41, e134.

 

6、Xie, M., Haellman, V. and Fussenegger, M. Synthetic biology - application-oriented cell engineering. Current Opinion in Biotechnology (2016) 40, 139-148.

 

7、Xie, M., Aubel, D. and Fussenegger, M. Closed-Loop Control Systems – the Quest for Precision Medicines for Diabetes. Current Opinion in Systems Biology (2017) 5, 32-40.

 

8、Xie, M. and Fussenegger, M. Mammalian designer cells: Engineering principles and biomedical applications. Biotechnology Journal (2015) 10, 1005-1018.

 

9、Wang, H., Xie, M., Charpin-El Hamri, G., Ye, H. and Fussenegger, M. Treatment of chronic pain by designer cells controlled by spearmint aromatherapy. Nature Biomedical Engineering (2018) 2, 114–123.

 

10、Bojar, D., Scheller, L., Charpin-El Hamri, G., Xie, M. and Fussenegger, M. Caffeine-inducible gene switches controlling experimental diabetes. Nature Communications (2018) 9:2318.

 

11、Shao, J., Xue, S., Yu, G., Yu, Y., Yang, X., Bai, Y., Zhu, S., Yang, L., Yin, J., Wang, Y., Liao, S., Guo, S., Xie, M., Fussenegger, M. and Ye, H. Smartphone-controlled optogenetically engineered cells enable semi-automatic glucose homeostasis in diabetic mice. Science Translational Medicine (2017) 9, eaal2298.

 

12、Wang, H., Ye, H., Xie, M., Daoud El-Baba, M. and Fussenegger, M. Cosmetics-triggered percutaneous remote control of transgene expression in mice. Nucleic acids research (2015) 43, e91.

 

13、Xue, S., Yin, J., Shao, J., Yu, Y., Yang, L., Wang, Y., Xie, M., Fussenegger, M. and Ye, H. A Synthetic-Biology-Inspired Therapeutic Strategy for Targeting and Treating Hepatogenous Diabetes. Molecular Therapy (2017) 25, 2.

 

14、Bai, P., Ye, H., Xie, M., Saxena, P., Zulewski, H., Charpin-El Hamri, G., Djonov, V. and Fussenegger, M. A synthetic biology-based device prevents liver injury in mice. Journal of Heptatology (2016) 65, 84-94.

 

15、Liu, Y., Bai, P., Woischnig, A., Charpin-El Hamri, G., Ye, H., Folcher, M., Xie, M., Khanna, N. and Fussenegger, M. Immunomimetic designer cells protect mice from methicillin-resistant Staphylococcus aureus infection. Cell (2018) 174, 1-12.

 

四、   人才招聘

本实验室开始招收博士生,以及博士后、科研助理和行政助理等!非常期待希望在合成生物学相关领域干一番事业的你们加盟!

博士生招生计划:

博士招生具体要求请参照西湖大学官网,招收专业如下:

招生学科1(专业):分子生物学(生物信息学 / 生物化学/ 细胞生物学)

Discipline 1: Molecular Biology (Cell Biology, Biochemistry, Bioinformatics & Systems Biology)

招生学科2(专业):基础医学(医学系统生物学 / 医学信息学 / 分子医学/免疫学 )

Discipline 2: Basic Medical Sciences (Molecular Medicine, Immunology, Biomedical Engineering, Medical Technology)

 

五、   联系方式

电子邮箱:xiemingqi@westlake.edu.cn