|


郑钜圣博士

     Ju-Sheng Zheng, Ph. D. 

 证据射门个.jpg

 

“愿在西子湖畔,你我共同见证西湖大学的成长和腾飞,共同为中国营养科学的发展贡献力量,共同为探索生命的奥秘和改善人类的健康而奋斗。”

 

一、 个人简历 

郑钜圣(1987-),浙江天台人。2009年毕业于宁波大学,获得学士学位;2014年毕业于浙江大学,获得博士学位,从事营养流行病学研究;2011-2012年,作为联合培养博士生,在美国塔夫茨大学人类老年营养研究中心从事营养遗传学研究;2015年-2018年在英国剑桥大学临床医学院从事遗传流行病学和营养学博士后研究工作,欧盟玛丽居里学者(Marie Skłodowska-Curie Individual Fellow)。2018年9月加入西湖大学生命科学学院,担任独立课题组负责人(PI)、特聘研究员、博士生导师,成立人类营养与流行病实验室(实验室网站www.wenutrition.net)。

 

二、  研究方向

(1) 结合营养学、流行病学及营养基因组学与代谢组学等多组学手段探索多种营养素(包括omega-3脂肪酸、维生素D,维生素C,类胡萝卜素等)的遗传基础及这些营养素在2型糖尿病、肥胖等代谢性疾病发生发展中的作用及相关机理,并利用临床干预和孟德尔随机化分析方法探索营养素与代谢性疾病的因果关系;

(2)从膳食营养-肠道微生态-人类遗传变异三者的交互作用角度研究营养与代谢性疾病的关联,致力于开发基于个性化营养的疾病防治新策略;

(3)利用大型队列研究探索孕期及婴幼儿早期喂养方式和营养对儿童肥胖的影响,探索中国儿童肥胖的成因及制定干预策略;

(4)食品营养学研究,功能性食品的开发、营养评价及机理研究。

 

三、  代表论文(*通讯作者)

1. Zheng JS*, Imamura F, Sharp SJ, et al. Changes in plasma phospholipid fatty acids over 13 years and correlates of change: EPIC-Norfolk Study. Am J Clin Nutr 2019, in press (https://doi.org/10.1093/ajcn/nqz030)

2. Zheng JS*, Imamura F, Sharp SJ, et al. Association of plasma vitamin D metabolites with incident type 2 diabetes: EPIC-InterAct case-cohort study. J Clin Endocrinol Metab 2019, 104(4): 1293-1303.

3. Zheng JS*, Lin JS, Dong HL, Zeng FF, Li D, Song Y, Chen Y*. Association of erythrocyte n-3 polyunsaturated fatty acids with incident type 2 diabetes in a Chinese population. Clin Nutr 2018, in press.( https://doi.org/10.1016/j.clnu.2018.09.018)

4. Zheng JS*, Chen J, Wang L, Yang H, Fang L, Yu Y, Yuan L, Feng J, Li K, Tang J, Lin M, Lai CQ, Li D*. Replication of a gene-diet interaction at CD36, NOS3 and PPARG in response to omega-3 fatty acid supplements on blood lipids: A double-blind randomized controlled trial. EBioMedicine 2018, 31:150-156.

5. Zheng JS*, Sharp SJ, Imamura F, et al. Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct Study. BMC Med 2017,15:203.

6. Zheng JS, Liu H, Ong KK, Huang T, Guan Y, Huang Y, Yang B, Wang F, Li D. Maternal blood pressure rise during pregnancy and offspring obesity risk at 4-7 years old: the Jiaxing Birth Cohort. J Clin Endocrinol Metab 2017, 102(11):4315-4322.

7. Zheng JS, Lin M, Fang L, Yu Y, Yuan L, Jin Y, Feng J, Wang L, Yang H, Chen W, Tang J, Cai W, Shi M, Li Z, Wang F, Li D. Effects of n-3 fatty acid supplements on glycemic traits in Chinese type 2 diabetic patients: a double-blind randomized controlled trial. Mol Nutr & Food Res 2016, 60(10):2176-2184.

8. Zheng JS, Liu HJ, Zhao YM, Li J, Chen Y, Zhu S, Chen H, Huang T, Li D. Complementary feeding and childhood adiposity in preschool-aged children in a large Chinese cohort. J Pediatrics 2015, 166(2):326-31.

9. Zheng JS, Lai CQ, Parnell LD, Lee YC, Shen J, Smith CE, Casas-Agustench P, Richardson K, Li D, Arnett DK, Borechi IB, Ordovas JM. Genome-wide interaction of genotype by erythrocyte n-3 fatty acids contributes to phenotypic variance of diabetes-related traits. BMC Genomics 2014, 15:781.

10. Zheng JS, Parnell LD, Smith CE, Lee YC, Jamal-Allial A, Ma Y, Li D, Tucker KL, Ordovas JM, Lai CQ. Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641 and insulin resistance: replication of a gene-nutrient interaction in four populations of different ancestries. Clin Chem 2014, 60(1):186-96.

11. Zheng JS, Liu HJ, Li J, Chen Y, Wei C, Shen G, Zhu S, Zhao YM, Huang T, Li D. Exclusive breastfeeding and childhood overweight in Jiaxing Birth Cohort: a large cohort study in China. J Nutr 2014, 144(9):1454-59.

12. Zheng JS, Hu XJ, Zhao YM, Yang J, Li D. Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. BMJ 2013, 346:f3706.

13. Zheng JS, Arnett DK, Parnell LD, Smith CE, Li D, Borecki IB, Tucker KL, Ordovas JM, Lai CQ. Modulation by dietary fat and carbohydrate of IRS1 association with type 2 diabetes traits in two populations of different ancestries. Diabetes Care 2013, 36(9):2621-7.

14. Zheng JS, Huang T, Yu Y, Hu X, Yang B, Li D. Fish consumption and CHD mortality: an updated meta-analysis of seventeen cohort studies. Public Health Nutr 2012, 15(4):725-737. (ESI highly cited paper)

 

Full list of publications:

ResearchGate: https://www.researchgate.net/profile/Ju_Sheng_Zheng

PubMedhttps://www.ncbi.nlm.nih.gov/pubmed/?term=ju-sheng+zheng+or+jusheng+zheng


四、联系方式

电子邮箱:zhengjusheng@westlake.edu.cn

电话:+86-0571-86915303

欢迎有志于人工智能、营养学、遗传学与肠道微生物组学等多学科交叉研究的朋友加盟本实验室,本实验室提供助理研究员、副研究员等岗位。