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邓力 博士

Li Deng, Ph. D.


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创新不仅需要智慧,也需要梦想和激情。西湖大学是一个让大家追随激情、发挥智慧而实现梦想的地方。

 

一、个人简介

邓力,1965年生,世界知名有机合成化学家,有机催化领域的创始者和引领者之一。1987年毕业于清华大学化学系,获学士学位;1990年获美国威斯康辛大学有机化学硕士学位;1995年获哈佛大学有机化学博士,随后在哈佛大学从事博士后工作。1995至2018年,历任美国布兰代斯大学化学系助理教授、副教授(终身教职)、正教授,2005年被聘为首任Orrie Friedman讲席教授;2011-2014年担任布兰代斯大学化学系主任。现为西湖大学讲席教授,理学院执行院长。

二、学术成果

邓力教授在有机催化领域开展了原创而系统性的研究工作,取得了一系列国际同行公认具有广泛影响力的奠基性学术成果。他在Nature,J. Am. Chem. Soc., Angewandte Chemie等化学顶尖杂志上发表了多篇深远影响力的文章。他的工作得到来自于世界各地学术界同行的广泛地引用,他所发明报道的催化剂和化学反应已被应用于工业界,很多催化剂已授权给知名试剂和大制药公司开发使用。

邓力教授还担任Nature,J. Am. Chem. Soc., Angewandte Chemie, Nature Chemistry 等多家国际著名学术期刊的审稿人以及美国、 欧洲、 日本、加拿大、香港和新加坡多家学术机构及基金评审专家。他多次获奖,包括Sloan Research Fellow, JSPS (Japan Society for the Promotion of Sciences) Fellow,以及在华人化学家中享有盛名的The Chan Memorial Award in Organic Chemistry

邓力教授研究小组自2015年以来在NatureJ. Am. Chem. Soc.上报道了一系列接近生物酶效率的新型有机分子催化剂,实现了一系列高价值新反应的开发,这些成果代表了当今有机催化领域的最新进展和最高水平。他计划于西湖大学化学系建立世界一流水平的催化及合成化学研究中心。

 

三、代表论文(*代表通信作者)

1. Chen, Y.; Tian, S.-K.; Deng, L.* "A Highly Enantioselective Catalytic Desymmetrization of Cyclic Anhydrides with Modified Cinchona Alkaloids," J. Am. Chem. Soc. 2000/09, 122, 9542-9543.

2. Tian, S.-K.; Deng, L.* "A Highly Enantioselective Chiral Lewis Base-Catalyzed Asymmetric Cyanation of Ketones," J. Am. Chem. Soc. 2001/06, 123, 6195-6196.

3. McDaid, P.; Chen, Y.; Deng, L.* “A Highly Enantioselective and General Conjugate Addition of Thiols to Cyclic Enones with an Organic Catalyst,” Angew. Chem. Int. Ed. 2002/01, 41, 338-340. Angew. Chem. 2002/01, 114, 348-350. (Designated as a “Hot Paper”).

4. Tian, S.-K.; Hong, R.; Deng, L.* “Catalytic Asymmetric Cyanosilylation of Ketones with Chiral Lewis Base,” J. Am. Chem. Soc. 2003/07, 125, 9900-9901.

5. Tian, S.-K.; Chen, Y.; Hang, Jianfeng.; Tang, Liang.; McDaid, P.; Deng, L.* “Asymmetric Organic Catalysis with Modified Cinchona Alkaloids,” Accounts of Chemical Research 2004/05, 37, 621-631 (invited contribution for a special issue of asymmetric organic catalysis).

6. Li, H.; Wang, Y.; Tang, L.; Deng, L.* “Highly Enantioselective Conjugate Addition of Malonate and -Ketoester to Nitroalkenes: Asymmetric C-C Bond Formation via New Bifunctional Organic Catalysts Based on Cinchona Alkaloids,” J. Am. Chem. Soc. 2004/07, 126, 9906-9907.

7. Li, H.; Wang, Y.; Tang, L.; Wu, F.; Liu, X.; Guo, C.; Foxman, B.; Deng, L.* “Stereocontrolled Creation of Adjacent Quaternary and Tertiary Stereocenters via a Catalytic, Diastereoselective and Enantioselective Conjugate Addition,” Angew. Chem. Int. Ed. 2004/12, 44, 105-108 (designated as a “Very Important Paper (VIP)” paper).

8. Li, H.; Song, J.; Liu, X.; Deng, L.* “Catalytic Enantioselective Conjugate Additions with Vinyl Sulfones,” J. Am. Chem. Soc. 2005/06, 127, 8948-8949.

9. Li, H.; Wang, B.; Deng, L.* “Enantioselective Nitroaldol Reaction of -Ketoesters Catalyzed by Cinchona Alkaloids,” J. Am. Chem. Soc. 2005/12, 128, 732-733.

10. Wang, Y.; Liu, X.; Deng, L.* “Dual-Function Cinchona Alkaloid Catalysis: Catalytic Asymmetric Tandem Conjugate Addition-Protonation for the Direct Creation of Nonadjacent Stereocenters,” J. Am. Chem. Soc. 2006/03, 128, 3928‑3930.

11. Wu, F.-H.; Li, H.; Hong, R.; Deng, L.* “Construction of Quaternary Stereocenters via Efficient and Practical Conjugate Additions to α,β Unsaturated Ketones with a Chiral Organic Catalyst,” Angew. Chem. Int. Ed. 2006/01, 45, 947-950.

12. Song, J.; Wang, Y.; Deng, L.* “The Mannich Reaction of Malonates with Simple Imines Catalyzed by Bifunctional Cinchona Alkaloids: Enantioselective Synthesis of -Amino Acids,” J. Am. Chem. Soc. 2006/04, 128, 6048-6049.

13. Wang, B.; Wu, F.; Wang, Y.; Liu, X.; Deng, L.* “Control of Diastereoselectivity in Tandem Asymmetric Reactions Generating Nonadjacent Stereocenters with Bifunctional Catalysis by Cinchona Alkaloids,” J. Am. Chem. Soc. 2007/01, 129, 768‑769.

14. Wang, Y.; Li, H.; Wang, Y.-Q.; Liu, Y.; Foxman, B. M.; Deng, L. “Asymmetric Diels-Alder Reactions of 2-Pyrones with Bifunctional Organic Catalysts,” J. Am. Chem. Soc. 2007/05, 129, 6364-6365.

15. Lu, X.; Liu, Y.; Sun, B.; Cindric, B.; Deng, L.* “Catalytic Enantioselective Peroxidation of -Unsaturated Ketones,” J. Am. Chem. Soc. 2008/06, 130, 8134-8135 (Selected by editors for a “JACS Select collection” focused on organocatalysis).

16. Wu, Y.; Singh, R.; Deng, L.* “Asymmetric Olefin Isomerization via Proton Transfer Catalysis with an Organic Molecule” J. Am. Chem. Soc. 2011/07, 133, 12458-12461.

17. Wu Y.; Deng, L.* “Asymmetric Synthesis of Trifluoromethylated Amines via Catalytic Enantioselective Isomerization of Imines” J. Am. Chem. Soc. 2012/08, 134, 14334–14337.

18. Wu. Y.; Hu, L.; Li, Zhe.; Deng, L.* “Catalytic Asymmetric Umpolung Reactions of Imines” Nature 2015/07, 523, 445-450.

19. Zhou, X.; Wu, Y.; Deng, L.* “Cinchonium Betaines as Efficient Catalysts for Asymmetric Proton Transfer Catalysis: The Development of a Practical Enantioselective Isomerization of Trifluoromethyl Imines” J. Am. Chem. Soc., 2016/08, 138, 12297–12302.

20. Li, Z.; Hu, B.; Wu, Y.; Fei, C.; Deng, L.* “Control of Chemoselectivity in Asymmetric Tandem Reactions: Direct Synthesis of Chiral Amines Bearing Non-adjacent Stereocenters” PNAS, 2018/02, 115, 1730-1735.

 

四、联系方式

电子邮箱:dengli@westlake.edu.cn