Qiang Zhou, Ph. D.
Lofty aspirations, always striving for vanguard.
Single particle cryo electron microscopy (EM), which emerged several decades ago, has been revolutionized in recent several years since the breakthrough of hardware and software, becoming a powerful tool for the structural determination of biological macromolecules, which are preserved in their native state by quickly freezing into coolant at liquid nitrogen temperature.
Dr. Zhou’s previous research mainly focused on the structure determination of the membrane proteins or the biological macromolecule complexes with single particle cryo EM, which requires no crystals and only a small amount of samples. He has solved several 3D structures with his co-workers and collaborators, including inflammasomes, SNAP/SNARE complex in 20S particle, NPC1 and the voltage-gated sodium channels, providing structural bases to understand their working mechanisms. Dr. Zhou and his co-workers have solved the complex of the sodium channel and tetrodotoxin, a famous toxin from puffer fish, at a resolution of 2.6 Angstrom in a recent work, which is the highest resolution for membrane protein structures solved by single particle cryo EM, establishing the foundation for the structure-based drug design in future. In the years to come, Dr. Zhou’s lab will keep on the 3D structure determination and mechanism study of membrane proteins and macromolecular complexes involved in the important human diseases and physiological processes.
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